Liao, H. L. and Hu, M. K. Synthesis and anticancer activities of 5,6,7-trimethylbaicalein derivatives. Planta Med 2010;76(7):678-682. View abstract. B., Blach-Olszewska, Z., and Aliev, G. Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. 2007;45(3):403-411. View abstract. View abstract. J Med Food 2007;10:442-51. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. Here we will discuss the prominent benefits and side effects of the ScutellariaBaicalensisExtractBaicalin herb produced in China. Zhang, S., Jin, Y., Zhu, W., Tang, J., Hu, S., Zhou, T., and Chen, X. Baicalin released from Scutellaria baicalensis induces autotoxicity and promotes soilborn pathogens. To avoid any unwanted skin irritation you should consult with a doctor, dermatologist or trained professional before applying the ingredient onto the skin. Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others. Planta Med 2000;66(8):694-698. Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study. View abstract. Do not take Baikal skullcap if you are taking medications for an overactive thyroid. J Dermatol Sci 2007;46(1):31-40. Birth Defects Res B Dev.Reprod.Toxicol. Yao Xue.Xue.Bao. In some cases, this might change the effects and side effects of a medication. Case ReportsAcute liver injury: In patients with arthritis, following consumption of a formula containing baicalin derived from S. baicalensis or Chinese skullcap. J Med Food 2014;17(6):707-13. Jianjun, J. and Huiru, D. Preparation of high-purity baicalein from Scutellaria baicalensis Georgi. Liu, C. Z. and Chen, D. W. [Sanhuang tablets research]. Bochorakova, H., Paulova, H., Slanina, J., Musil, P., and Taborska, E. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Children: Baikal skullcap is POSSIBLY SAFE in children when given intravenously (by IV) by a healthcare provider, short-term. Chinese medicinal herbs modulate mutagenesis, DNA binding and metabolism of benzo[a]pyrene 7,8-dihydrodiol and benzo[a]pyrene 7,8-dihydrodiol-9,10-epoxide. With cancer, where you get treated first matters. J Ethnopharmacol. Opposite expression of securin and gamma-H2AX regulates baicalein-induced cancer cell death. The root of Scutellaria baicalensis (SB) traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer effects. 2010;36(3):329-338. View abstract. View abstract. View abstract. Int J Oncol. J Ethnopharmacol. View abstract. View abstract. Involvement of p53 in oroxylin A-induced apoptosis in cancer cells. Skullcap should not be used during pregnancy or breastfeeding. View abstract. View abstract. Call a physician if symptoms develop or persist. View abstract. Gabrielska, J., Oszmianski, J., Zylka, R., and Komorowska, M. Antioxidant activity of flavones from Scutellaria baicalensis in lecithin liposomes. Curr Drug Targets.Cardiovasc.Haematol.Disord 2005;5(2):177-184. Nutr Res 2009;29:298-304. Baicalein protects against doxorubicin-induced cardiotoxicity by attenuation of mitochondrial oxidant injury and JNK activation. 2011;31(4):1130-1132. Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. There are a number of different names that people use for Baicalin. 2nd ed. View abstract. ]. View abstract. Treatment of acute bronchiolitis with Chinese herbs. Baikal skullcap might also cause sleepiness and drowsiness. View abstract. In using this website you agree that neither Memorial Sloan Kettering nor any other party is or will be liable or otherwise responsible for any decision made or any action taken or any action not taken due to your use of any information presented at this website. Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of. Monitor your blood sugar closely. However, low doses of baicalin upregulated expression of multiple angiogenic genes to increase cell proliferation in developing blood vessels, while high doses inhibited angiogenesis by inducing cell death, suggesting dose-dependent dual effects. Yang, L., Zheng, X. L., Sun, H., Zhong, Y. J., Wang, Q., He, H. N., Shi, X. W., Zhou, B., Li, J. K., Lin, Y., Zhang, L., and Wang, X. Catalase suppression-mediated H(2)O(2) accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-kappaB activation and sensitizes apoptosis. Jeong, K., Shin, Y. C., Park, S., Park, J. S., Kim, N., Um, J. Y., Go, H., Sun, S., Lee, S., Park, W., Choi, Y., Song, Y., Kim, G., Jeon, C., Park, J., Lee, K., Bang, O., and Ko, S. G. Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice. The purpose of this study was to investigate whether SB exhibited anticancer activity in EGFR TKI-resistant lung cancer cells and to explore the underlying mechanism. View abstract. Macrophages are immune cells that are involved in your bodys inflammation response. Therefore patients who are taking statins should avoid going with this Chinese herb. View abstract. View abstract. Cancer Chemother.Pharmacol 2011;67(5):1063-1072. View abstract. Available at: https://www.cancer.gov/about-cancer/treatment/cam/hp/pc-spes-pdq. These include the Chinese Skullcap, Huang Qin, Scutellaria baicalensis (the scientific name), and the Hooded Willow Herb. Side effects are few and may include drowsiness. Side effects are few and may include drowsiness. Smol'ianinov ES, Gol'dberg VE, Matiash MG, et al. By inhibiting tyrosinase, Scutellaria baicalensis root extract may be able to reduce abnormal pigmentation associated with aging and exposure to UV light. Hui KM, Wang XH, Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. Gasiorowski, K., Lamer-Zarawska, E., Leszek, J., Parvathaneni, K., Yendluri, B. B., Ro, J. Y., and Woo, S. S. Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis. Eksp Klin Farmakol 1997;60:28-30. View abstract. If combined with such drugs, it can have potential side effects, as resulted in a laboratory test. Watanabe S, Kitade Y, Maski T, Nishioba M, Satoh K, Nishino H. Effects of lycopene and Sho-saiko-to on hepatocarcinogenesis in a rat model of sponstaneous liver cancer. A., Ruscetti, F. W., and Wang, J. M. Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Krakauer, T., Li, B. Q., and Young, H. A. A sugar beet-derived amino acid derivative with nice skin protection and moisturization properties.Betaine's special thing is being an osmolyte, a molecule that helps to control cell-water balance.It is also a natural osmoprotectant, meaning that it attracts water away from the protein surface and thus protects them from denaturation and Zhang CZ, Wang SX, Zhang Y, et al. 11-28-2000;160(2):219-228. 2013;140:22-30. Chang, H. H., Yi, P. L., Cheng, C. H., Lu, C. Y., Hsiao, Y. T., Tsai, Y. F., Li, C. L., and Chang, F. C. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. CAS #:94279-99-9 | EC #:304-845-9. Ciesielska, E., Wolszczak, M., Gulanowski, B., Szulawska, A., Kochman, A., and Metodiewa, D. In vitro antileukemic, antioxidant and prooxidant activities of Antoksyd S (C/E/XXI): a comparison with baicalin and baicalein. Tell your healthcare providers about any dietary supplements youre taking, such as herbs, vitamins, minerals, and natural or home remedies. View abstract. View abstract. Biol Pharm Bull 2011;34(5):727-733. View abstract. Extracts were added in the amount of 2.0 g/100 g of meat batter. Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. Chinese Journal of Gerontology 2010;30(7):926-928. View abstract. Pharmacotherapy 2010;30(7):750, 258e-750, 262e. View abstract. J Chromatogr.B Analyt.Technol Biomed.Life Sci 4-15-2011;879(13-14):1023-1028. S. barbata possesses a range of antitumor activities via multiple intracellular targets(20), with major anticancer constituents identified as scutellarin, apigenin5-O--glucopyranoside, apigenin, p-coumaric acid, luteolin and 4-hydroxywogonin(22). Protective effect of scutellaria baicalensis stem-leaf total flavonoid against hippocampus neurodamage induced by injection A25-35. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. View abstract. Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy. View abstract. View abstract. Zhang, X. W., Li, W. F., Li, W. W., Ren, K. H., Fan, C. M., Chen, Y. Y., and Shen, Y. L. Protective effects of the aqueous extract of Scutellaria baicalensis against acrolein-induced oxidative stress in cultured human umbilical vein endothelial cells. View abstract. Bioorg.Med Chem 8-1-2008;16(15):7516-7524. View abstract. Concentration-dependent inhibitory effects of baicalin on the metabolism of dextromethorphan, a dual probe of CYP2D and CYP3A, in rats. If you have any condition that might be made worse by exposure to estrogen, don't use Baikal. View abstract. Food Chem Toxicol. View abstract. View abstract. 2020 May;82(5):307-309. Beijing Da.Xue.Xue.Bao. Chen, C. S., Chen, N. J., Lin, L. W., Hsieh, C. C., Chen, G. W., and Hsieh, M. T. Effects of Scutellariae Radix on gene expression in HEK 293 cells using cDNA microarray. In vitro and in vivo antitumor activity of scutebarbatine A on human lung carcinoma A549 cell lines. Phytother Res 2000;14:210-2. Lee, Y. M., Cheng, P. Y., Chim, L. S., Kung, C. W., Ka, S. M., Chung, M. T., and Sheu, J. R. Baicalein, an active component of Scutellaria baicalensis Georgi, improves cardiac contractile function in endotoxaemic rats via induction of heme oxygenase-1 and suppression of inflammatory responses. Therapeutic effect of Scutellaria baicalensis on L-thyroxine-induced hyperthyroidism rats. It is also used as a diuretic, and should not be confused with Scutellaria baicalensis. Tsao, T. F., Newman, M. G., Kwok, Y. Y., and Horikoshi, A. K. Effect of Chinese and western antimicrobial agents on selected oral bacteria. Phytother Res 2000;14:210-2. Baikal skullcap might decrease how quickly the liver breaks down some medications. Morgan SL, Baggott JE, Moreland L, et al. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel Baikal skullcap might change how these pumps work and change how much medication stays in the body. Lee, E., Enomoto, R., Suzuki, C., Ohno, M., Ohashi, T., Miyauchi, A., Tanimoto, E., Maeda, K., Hirano, H., Yokoi, T., and Sugahara, C. Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. J Ethnopharmacol. Udintsev, S. N., Razina, T. G., and Iaremenko, K. V. [The antitumor effect of Baikal skullcap]. Wang, Z. Li, T., Li, N., Guo, Q., Ji, H., Zhao, D., Xie, S., Li, X., Qiu, Z., Han, D., Chen, X., and You, Q. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. Natural Product Sciences 2008;14(3):182-186. Huang KC. Baikal skullcap might slow blood clotting. Nat Prod Res 2008;22(16):1410-1412. Nahrung 2004;48(2):123-128. 1995;15(8):465-467. J Chem Ecol. J Altern Complement Med 2002;8(5):567-572. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. Chang, W. H., Chen, C. H., and Lu, F. J. Pediatr Dermatol 2006;23:507-10. Int J Mol Med 2004;14(4):627-632. Li L, Gao H, Lou K, et al. Shih, H. C., Hsu, C. S., and Yang, L. L. In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. View abstract. Mu, X., He, G., Cheng, Y., Li, X., Xu, B., and Du, G. Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro. Z., Wang, Y., and Liu, B. Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo. In combination with other herbs, Baikal skullcap is used to treat attention deficit-hyperactivity disorder (ADHD), prostate cancer, a lung condition called bronchiolitis, arthritis, and hemorrhoids. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. J Med Food 2009;12:1143-8. Arch Dis Child 1993;68:468-71. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Scutellarin protects against the liver injury induced by diosbulbin B in mice and its mechanism. View abstract. The root is used to make medicine. Clin Cancer Res 5-15-2005;11(10):3905-3914. Ann Intern Med 2012;156:857-60. Konoshima, T., Kokumai, M., Kozuka, M., Iinuma, M., Mizuno, M., Tanaka, T., Tokuda, H., Nishino, H., and Iwashima, A. Diabetes medicines: These Int J Antimicrob.Agents 2009;34(3):284-285. Shin NR, Gu N, Choi HS, Kim H. Combined effects of Scutellaria baicalensis with metformin on glucose tolerance of patients with type 2 diabetes via gut microbiota modulation. This could increase how much lithium is in the body and result in serious side effects. 1. WebScutellaria Baicalensis Extract. An intravenous preparation that includes Baikal skullcap, forsythia, and honeysuckle has been used under medical supervision with apparent safety in children for up to 7 days. A., Lee, K., Hwangbo, H., Park, E., Kim, M., and Ma, W. Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography. Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy. Acta Pharmacol Sin. Arch Dis Child 1993;68:468-71. 2007;45(3):403-411. Total flavonoids induced increases in DNA fragmentation and mitochondrial pathway apoptosis(30). Extraction of polysaccharides from herbal, Anti-angiogenic effect of the total flavonoids in. Li, B. Q., Fu, T., Yan, Y. D., Baylor, N. W., Ruscetti, F. W., and Kung, H. F. Inhibition of HIV infection by baicalin--a flavonoid compound purified from Chinese herbal medicine. Yeh J.H, Chiu H.F, Wang J.S., and et al. Ann Intern Med 2012;156:857-60. Z., Jing, X. L., Guo, X. H., and Zhu, Y. Y. Cancer Sci 2008;99(4):689-695. Blood 2-15-2008;111(4):2354-2363. International Journal of Pharmacology 2010;6(2):81-88. View abstract. Ceska.Slov.Farm. J Nat Prod 1998;61:1413-5. But there is not enough information to know if Baikal skullcap is the cause of these side effects. In Vivo 2004;18(4):497-503. Dry extract of Scutellaria baicalensis as a hemostimulant in antineoplastic chemotherapy in patients with lung cancer. Gao, J., Morgan, W. A., Sanchez-Medina, A., and Corcoran, O. It is used with other herbs in traditional Chinese medicine to treat bacterial infections, hepatitis, and tumors. View abstract. The antiinflammatory and analgesic effects of baicalin in carrageenan-evoked thermal hyperalgesia. The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. However, both S. baicalensis root and its main flavonoid baicalin appear to have dose-dependent pro- and anti-angiogenic effects . Song, S. J., Li, F. F., Xu, Y., Zhang, L. H., Yuan, F., and Zhang, Y. Yang, X., Huang, S., Chen, J., Song, N., Wang, L., Zhang, Z., Deng, G., Zheng, H., Zhu, X. Q., and Lu, F. Evaluation of the adjuvant properties of Astragalus membranaceus and Scutellaria baicalensis GEORGI in the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models. Further studies are needed. Razina, T. G., Udintsev, S. N., Tiutrin, I. I., Borovskaia, T. G., and Iaremenko, K. V. [The role of thrombocyte aggregation function in the mechanism of the antimetastatic action of an extract of Baikal skullcap]. But there isn't enough information to know if this is an important interaction. Baikal skullcap might change the levels of statins in your blood. Avoid skin and eye contact and breathing in dust. Reichenbach S, Juni P. Medical food and food supplements: not always as safe as generally assumed. PL-Detail Document, Liver Toxicity and Limbrel. Wang, G. F., Wu, Z. F., Wan, L., Wang, Q. T., and Chen, F. M. Influence of baicalin on the expression of receptor activator of nuclear factor-kappaB ligand in cultured human periodontal ligament cells. Daugel'-Dauge, N. O., Durnev, A. D., Kulakova, A. V., Seredenin, S. B., and Velichkovskii, B. T. [Corpuscular mutagenesis and its prevention]. View abstract. Regulska-Ilow, B., Biernat, J., Grajeta, H., Ilow, R., and Drzewicka, M. Influence of bioflavonoids from the radix extract of Scutellaria baicalensis on the level of serum lipids, and the development of laboratory rats fed with fresh and oxidized fats. 1999;385-6, 400-1. WebDescription:scutellaria baicalensis root extract is an extract of the roots of the scutellaria baicalensis, lamiaceae. Pharmacotherapy 2010;30(7):750, 258e-750, 262e. Lee, Y., Yeo, H., Liu, S. H., Jiang, Z., Savizky, R. M., Austin, D. J., and Cheng, Y. C. Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring. Ren S, Cao D., Yang J, and et al. The compound baicalein exhibited only inhibitory effects(9). Shih, H. C., Hsu, C. S., and Yang, L. L. In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. View abstract. Yin, F., Liu, J., Ji, X., Wang, Y., Zidichouski, J., and Zhang, J. Baicalin prevents the production of hydrogen peroxide and oxidative stress induced by Abeta aggregation in SH-SY5Y cells. Wu, J. Neuroprotective effects of flavonoids were ameliorated by diazepam, a GABA receptor agonist, suggesting that the components influence GABA receptor activity(5). Research shows that Chinese skullcap extract is toxic to cancer cells, such as brain tumor cells, prostate cancer cells, and head and neck squamous cell carcinoma cell lines. J Chromatogr.A 3-19-2010;1217(12):1875-1881. Zhou, X., Zhang, Q., Liang, H., Jiang, Y., Wang, X., Wang, B., and Zhao, Y. Pharmacist's Mol Nutr Food Res 2008;52(11):1349-1357. View abstract. Zhongguo Zhong.Yao Za Zhi 2007;32(17):1827-1829. Scutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional A., Sherstoboev, E. Y., Zueva, E. P., Razina, T. G., Amosova, E. N., and Krylova, S. G. Effect of baikal skullcap extract administered alone or in combination with cyclophosphamide on natural cytotoxicity system in mice with Lewis lung carcinoma. Bioorg.Med Chem 8-1-2008;16(15):7516-7524. You, J., Gao, S., Jin, H., Li, W., Zhang, H., and Yu, A. On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi. Chen et C. Ling and Scutellaria baicalensis Georgi. Regulska-Ilow, B., Biernat, J., Grajeta, H., Ilow, R., and Drzewicka, M. Influence of bioflavonoids from the radix extract of Scutellaria baicalensis on the level of serum lipids, and the development of laboratory rats fed with fresh and oxidized fats. A., Attele, A. S., Zhang, L., and Yuan, C. S. Anti-HIV activity of medicinal herbs: usage and potential development. Wu, J. Y., Chung, K. T., Liu, Y. W., Lu, F. J., Tsai, R. S., Chen, C. H., and Chen, C. H. Synthesis and biological evaluation of novel C(6) modified baicalein derivatives as antioxidative agents. Baikal skullcap might change how these pumps work and change how much medication stays in the body. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Puri BK, White N, Monro JA. Scutellaria baicalensis root: Uses, It might cause drowsiness. Guo, H. X., Liu, D. H., Ma, Y., Liu, J. F., Wang, Y., Du, Z. Y., Wang, X., Shen, J. K., and Peng, H. L. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Ye, F., Xui, L., Yi, J., Zhang, W., and Zhang, D. Y. Anticancer activity of Scutellaria baicalensis and its potential mechanism. Lee, S., Kim, D. H., Jung, J. W., Oh, J. H., Park, H. J., Park, C., Huh, Y., Cheong, J. H., Oh, T. H., and Ryu, J. H. Schizandra chinensis and Scutellaria baicalensis counter stress behaviors in mice. Go, W. J., Ryu, J. H., Qiang, F., and Han, H. K. Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux. Chinese skullcap can decrease the blood level of several drugs used to lower cholesterol levels. Mol Pharmacol 2001;60(3):507-513. WebSide Effects Precautions Interactions Dosing Reviews (4) Overview Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. Ceska.Slov.Farm. Kim, D. S., Son, E. J., Kim, M., Heo, Y. M., Nam, J. Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. View abstract. Baikal skullcap can also affect most peoples blood sugar levels, but people with diabetes can get negative results with the herb. The appropriate dose of Baikal skullcap depends on several factors such as the user's age, health, and several other conditions. Mol Urol. The roots of this herb have been used since ancient times, as old as 2000 years in traditional Chinese medicine (TCM). View abstract. Liu, S., Ma, Z., Cai, H., Li, Q., Rong, W., and Kawano, M. Inhibitory effect of baicalein on IL-6-mediated signaling cascades in human myeloma cells. Analysis of essential oils from different organs of Scutellaria baicalensis. View abstract. No matter new buyer or old purchaser, We believe in long expression and trusted relationship for Scutellaria Baicalensis Root, Nootropics Modafinil, Herbal Extract Oil, Maca Extract Liquid, Hawthorn Extract Vs Hawthorn Berry. Mol Pharmacol 2001;60(3):507-513. WebScutellaria baicalensis Root Dry No Data Extract 100 4. Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin. Eksp Klin Farmakol 1997;60:49-51. 2010;48(5):1202-1209. CAS #:94279-99-9 | EC #:304-845-9. Biochem Biophys Res Commun 9-24-2000;276(2):534-538. Planta Med 2006;72(14):1318-1321. (Elite.Ed) 2010;2:1538-1547. J Biomed.Sci 2009;16:27. The root has been used Statements made about products have not been evaluated by the Food and Drug Administration. Lin, X. C., Liu, X. G., Chen, X. W., Chen, W. Z., and Liang, N. C. [Inhibitory effect and its kinetic analysis of baicalein on recombinant human protein kinase CK2 holoenzyme]. View abstract. Eur J Haematol. Afr J Tradit.Complement Altern Med 2010;7(4):339-349. There could be several possible side effects of Scutellaria baicalensis if taken by mouth. Yimam, M., Zhao, Y., Ma, W., Jia, Q., Do, S. G., and Shin, J. H. 90-day oral toxicity study of UP446, a combination of defined extracts of Scutellaria baicalensis and Acacia catechu, in rats. Braude MR, Bassily R. Drug-induced liver injury secondary to Scutellaria baicalensis (Chinese skullcap). The growing interest in skin lightening has recently renewed attention on the esthetic applications of Chinese herbal medicine. J Altern Complement Med 2002;8(5):567-572. Heo, H., Shin, Y., Cho, W., Choi, Y., Kim, H., and Kwon, Y. K. Memory improvement in ibotenic acid induced model rats by extracts of Scutellaria baicalensis. 11-12-2009;126(2):320-331. Medications that cause sleepiness and drowsiness are called sedatives. Pharm Biol 2011;49(3):256-261. Bacteriostatic activity of combined application of Galla chinensis, Scutellaria baicalensis and Rhizoma coptidis against MRSA in vitro. View abstract. Chamaecyparis Obtusa Leaf Extract: Scutellaria Baicalensis Root Extract: soothing, antioxidant, antimicrobial/ antibacterial, moisturizer/ humectant: goodie: Cinnamomum Cassia Bark Extract: Sodium Hyaluronate: skin-identical ingredient, moisturizer/ humectant View abstract. View abstract. 4-12-2011;134(3):884-891. Zhongguo Zhong.Yao Za Zhi 2010;35(6):682-685. Gasiorowski, K., Lamer-Zarawska, E., Leszek, J., Parvathaneni, K., Yendluri, B. Morgan SL, Baggott JE, Moreland L, et al. Scutellaria Baicalensis ( Baical Skullcap ) is a plant. Khazanov, V. A. and Saifutdinov, R. R. [Mitochondrial mechanism of the anti-hypoxia effect of the Baikal scullcap extract]. View abstract. Li, H. N., Nie, F. F., Liu, W., Dai, Q. S., Lu, N., Qi, Q., Li, Z. Y., You, Q. D., and Guo, Q. L. Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo. View abstract. Visit the FDA MedWatch website or call 1-800-FDA-1088. Taking Baikal skullcap along with estrogen pills might decrease the effects of estrogen pills. 6-29-2001;500(1-2):52-55. Eksp.Klin Farmakol. 2009;29(1):211-213. Alcohol can cause sleepiness and drowsiness. Taking Baikal skullcap along with sedative medications might cause too much sleepiness. Surgery: Baikal skullcap might slow blood clotting. Biological properties of baicalein in cardiovascular system. Razina, T. G., Udintsev, S. N., Prishchep, T. P., and Iaremenko, K. V. [Enhancement of the selectivity of the action of the cytostatics cyclophosphane and 5-fluorouracil by using an extract of the Baikal skullcap in an experiment]. To avoid any Am J Chin Med 2011;39(4):693-704. Curr Neurol.Neurosci.Rep. View abstract. A., Lee, K., Hwangbo, H., Park, E., Kim, M., and Ma, W. Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography. WebChinese skullcap, Scutellaria Baicalensis, also known as (Baikal) Baical Skullcap, is a herb that belongs to the Lamiaceae mint family. The total content of these 6 main flavonoids account ed for 68.5% of the extract . Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. Armstrong, T. S. and Gilbert, M. R. Use of complementary and alternative medical therapy by patients with primary brain tumors. 11-28-2000;160(2):219-228. Go, W. J., Ryu, J. H., Qiang, F., and Han, H. K. Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux. The root of Scutellaria baicalensis (SB) traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer effects. Typical doses (see individual product information): Dried herb: 1 to 2 g 3 times/day; Tea: 240 mL 3 times/day (pour 250 mL of boiling water over 5 to 10 mL of the dried herb and steep for 10 to 15 minutes); Tincture: 2 to 4 mL 3 times/day. J Cell Biochem 10-1-2010;111(2):274-283. Indian J Med Res 2008;127(6):610-615. People use skullcap for anxiety, insomnia, and many Dry extract of Scutellaria baicalensis as a hemostimulant in antineoplastic chemotherapy in patients with lung cancer. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. Lin H, Zhou J, Lin K, et al. Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others. It's one of the most commonly used thickeners and emulsion stabilizers.If the product is too runny, a little xanthan gum will make it more gel-like. View abstract. View abstract. View abstract. View abstract. Allergic contact dermatitis to Tinosorb S, Scutellaria baicalensis, and other emerging allergens in cosmetics. Some cancer cell lines undergo cell death when exposed to extracts of this herb, but some compounds in this herb may actually have opposite effects. Maternal and Child Health Care of China 2011;26(10):1529-1531. This will help them manage your care and keep you safe. A Scutellaria Baicalensis Root Extract trade name mixture (30% ethanol extract) is reported to contain flavonoid compounds. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. View abstract. Zhou, J., Qu, F., Zhang, H. J., Zhuge, X. H., and Cheng, L. Z. View abstract. 2000;4(3):289-291. Pharmacol Biochem Behav 2009;92(4):642-648. You may ask and answer a query. Cheng, K. T., Hou, W. C., Huang, Y. C., and Wang, L. F. Baicalin induces differential expression of cytochrome C oxidase in human lung H441 cell. Lee, E., Enomoto, R., Suzuki, C., Ohno, M., Ohashi, T., Miyauchi, A., Tanimoto, E., Maeda, K., Hirano, H., Yokoi, T., and Sugahara, C. Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. Chinese Journal of Gerontology 2010;30(7):926-928. View abstract. View abstract. Do you know this herb by any other name ? J Biomed.Sci 2009;16:27. [Study of Scutellaria baicalensis and Baicalin against antimicrobial susceptibility of Helicobacter pylori strains in vitro]. However, it is not known if the herb would exert similar effects by itself, and cases of hepatotoxicity with some supplements have been reported(18)(24). Int J Cancer 5-1-2007;120(9):2019-2027. View abstract. Baikal skullcap might slow blood clotting. [14] Fu, J., Cao, H., Wang, N., Zheng, X., Lu, Y., Liu, X., Yang, D., Li, B., Zheng, J., and Zhou, H. An anti-sepsis monomer, 2',5,6',7-tetrahydroxyflavanonol (THF), identified from Scutellaria baicalensis Georgi neutralizes lipopolysaccharide in vitro and in vivo. Biochim Biophys Acta 1999;1472:643-50. View abstract. View abstract. 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